HSD11B1 rs846908 polymorphisms and tacrolimus concentrations: quantum chemical analysis and implication in patients with renal transplantation

Introduction Renal transplantation is the therapeutic of choice for the end stage renal disease. With advanced immunosuppressive drug, the outcome of renal transplantation becomes favorable in the present day (1). Tacrolimus is a widely used immunosuppressive drug for post-renal transplantation (2). The concentration of tacrolimus is important for success in management of the patient. The effect of genetic polymorphism on the concentration of tacrolimus is very interesting (3). Of several genes, the 11beta-hydroxysteroid dehydrogenase type 1 (HSD11B1) is widely discussed at present (4). Here, the author studied the HSD11B1 rs846908 polymorphisms and tacrolimus concentrations by quantum chemical analysis. It can be seen that the AA + AA polymorphism results in less finalized tacrolimus concentration comparing to GG + GA polymorphism.